Annette L. Bunge

Professor Emeritus

BS - State University of New York, Buffalo
PhD - University of California, Berkeley

Research Description

Manifestation of therapeutic or toxic effects following chemical contact with skin will only occur if there is dermal absorption. The ultimate objective of this research is to develop algorithms for predicting the rate and extent of absorption following dermal contact with a chemical. This prediction can then be used for health risk assessments or drug delivery and design. Research on this subject is conducted in collaboration with pharmaceutical chemists, toxicologists, dermatologists and computational scientists at several research facilities around the world. Our goals are to conduct experiments that produce well-defined and interpretable data, identify absorption mechanisms, and develop descriptive mathematical models of barrier membranes like skin.

selected Publications

Bunge AL, Persichetti JM and Payan JP, Explaining skin permeation of 2-butoxyethanol from neat and aqueous solutions, Int J Pharm, 435, 50-62, 2012. [doi: 10.1016/j.ijpharm.2012.01.058]

White EA, Horne A, Runciman J, Orazem ME, Navidi WC, Roper CS and Bunge AL, On the correlation between single-frequency impedance measurements and human skin permeability to water, Toxicol In Vitro, 25, 2095-2104, 2011. [doi: 10.1016/j.tiv.2011.09.011]

White EA, Orazem ME and Bunge AL, A critical analysis of single-frequency LCR databridge impedance measurements of human skin, Toxicol In Vitro, 25, 774-784, 2011. [doi: 10.1016/j.tiv.2011.01.013]

Williams PRD, Sahmel J, Knutsen J, Spencer J and Bunge AL, Dermal absorption of benzene in occupational settings: Estimating flux and applications for risk assessment, Crit Rev Toxicol, 41, 111-141, 2011. [doi: 10.3109/10408444.2010.530224]

Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy RH, Hadgraft J, Kasting GB, Lane ME and Roberts MS, Mathematical models of skin permeability: An overview, Int J Pharm, 418, 115-129, 2011. [doi: 10.1016/j.ijpharm.2011.02.023]

Deglin SE, Macalady DL and Bunge AL, Measuring the saturation limit of low-volatility organic compounds in soils implications for estimates of dermal absorption, Sci Total Environ, 408, 6100-6107, 2010. [doi: 10.1016/j.scitotenv.2010.08.042]