Annette L. Bunge

Professor Emeritus

BS - State University of New York, Buffalo
PhD - University of California, Berkeley

Research Description

Manifestation of therapeutic or toxic effects following chemical contact with skin will only occur if there is dermal absorption. The ultimate objective of this research is to develop algorithms for predicting the rate and extent of absorption following dermal contact with a chemical. This prediction can then be used for health risk assessments or drug delivery and design. Research on this subject is conducted in collaboration with pharmaceutical chemists, toxicologists, dermatologists and computational scientists at several research facilities around the world. Funded by EPA, FDA, NIOSH, and NSF, our goals are to conduct experiments that produce well-defined and interpretable data, identify absorption mechanisms, and develop descriptive mathematical models of barrier membranes like skin.

selected Publications

Spalt EW, Kissel JC, Shirai JH and Bunge AL, "Dermal absorption of environmental contaminants from soil and sediment: a critical review," Journal of Exposure Science and Environmental Epidemiology, 19, 119, 2009.

N'Dri-Stempfer B, Navidi WC, Guy RH and Bunge AL, "Improved Bioequivalence Assessment of Topical Dermatological Drug Products Using Dermatopharmacokinetics," Pharmaceutical Research, 26, 316, 2009.

Goodyer CE and Bunge AL, "Comparison of numerical simulations of barrier membranes with impermeable flakes," Journal of Membrane Science, 329, 209, 2009.

N'Dri-Stempfer B, Navidi WC, Guy RH and Bunge AL, "Optimizing metrics for the assessment of bioequivalence between topical drug products," Pharmaceutical Research, 25, 1621, 2008.

Norman AM, Kissel JC, Shirai JH, Smith JA, Stumbaugh KL and Bunge AL, "Effect of PBPK model structure on interpretation of in vivo human aqueous dermal exposure trials," Toxicological Sciences, 104, 210, 2008.

Ley EE and Bunge AL, "Chemical transport in silicone rubber membranes from pure powders and saturated aqueous solutions," Journal of Membrane Science, 292, 35, 2007.