Kevin J. Cash
Current molecular probes and sensor technologies present limitations in both the range of targets that can be measured and the ability to function in the complicated in vivo environment. My research program will help answer pressing biomedical questions by developing novel nanosensors that overcome these limitations and applying these new tools
Using this platform, I will focus my research on three distinct projects for which continuous monitoring can provide valuable information.
- Develop Enzyme Linked Nanosensors (ELiNS) to continuously monitor lactate levels during acute liver failure.
- Develop peptide targeted nanosensors for pH, pO2, pCO2, and lactate to monitor tumor metabolism during treatment.
- Develop fluorescence lifetime based nanosensors for improved cellular imaging in biofilms.
Cash, KJ, Clark, HA, “Phosphorescent Nanosensors for in Vivo Tracking of Histamine Levels”, Analytical Chemistry, 2013, 85, 6312-6318.
Cash, KJ, Clark, HA, “Nanosensors and Nanomaterials for Monitoring Glucose in Diabetes”, Trends in Molecular Medicine, 2010, 16, 584-593, PMCID.
Cash, KJ, Ricci, F, Plaxco, KW, “A General Electrochemical Method for Label-Free Screening of Protein-Small Molecule Interactions”, Chem. Commun. 2009, 6222-6224, PMCID.
Cash, KJ, Ricci, F, Plaxco, KW, “An Electrochemical Sensor for the Detection of Protein-Small Molecule Interactions Directly in Serum and Other Complex Matrices”, JACS, 2009, 131, 6955-6957, PMCID.
Cash, KJ, Heeger, AJ, Plaxco, KW, Xiao, Y, “Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum”, Analytical Chemistry, 2009, 81, 656-661, PMCID.