Assistant Professor, Chemical and Biological Engineering
Current molecular probes and sensor technologies present limitations in both the range of targets that can be measured and the ability to function in the complicated in vivo environment. My research program will help answer pressing biomedical questions by developing novel nanosensors that overcome these limitations and applying these new tools in situ. Traditional sensor designs, while being quite valuable for in vitro and laboratory analysis, often fail in vivo due to complications such as sensor invasiveness, sensitivity, selectivity, and limitations from the sensor readout mechanism. Polymeric nanosensors have emerged over the past several years as an excellent nanosensor design platform for continuous in vivo monitoring that overcomes the shortcomings of many traditional sensor designs.
Using this platform, I will focus my research on three distinct projects for which continuous monitoring can provide valuable information:
- Develop Enzyme Linked Nanosensors (ELiNS) to continuously monitor lactate levels during acute liver failure.
- Develop peptide targeted nanosensors for pH, pO2, pCO2, and lactate to monitor tumor metabolism during treatment.
- Develop fluorescence lifetime based nanosensors for improved cellular imaging in biofilms.
- BS – Northeastern University
- PhD – University of California, Santa Barbara
- Post-Doctoral Study – C.S. Draper Laboratory and Northeastern University
- Ferris MS, Katageri AG, Gohring GM, Cash KJ. A dual-indicator strategy for controlling the response of ionophore-based optical nanosensors. Sensors and Actuators B: Chemical. 2018 March; 256:674-681.
- Galyean AA, Behr MR, Cash KJ. Ionophore-based optical nanosensors incorporating hydrophobic carbon dots and a pH-sensitive quencher dye for sodium detection. Analyst. 2018 Jan 21;143(2):458-465. PubMed PMID: 29226289.
- Cash KJ, Li C, Xia J, Wang LV, Clark HA. Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo. ACS Nano. 2015 Feb 24;9(2):1692-8. PubMed PMID: 25588028; PubMed Central PMCID: PMC4364417.
- Awqatty B, Samaddar S, Cash KJ, Clark HA, Dubach JM. Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range. Analyst. 2014 Oct 21;139(20):5230-8. PubMed PMID: 25126649.
- Cash, KJ, Clark, HA, “Phosphorescent Nanosensors for in Vivo Tracking of Histamine Levels”, Analytical Chemistry, 2013, 85, 6312-6318.
- Cash, KJ, Clark, HA, “In Vivo Histamine Optical Nanosensors”, Sensors, 2012, 12, 11922-11932, PMCID.
- Cash, KJ, Clark, HA, “Nanosensors and Nanomaterials for Monitoring Glucose in Diabetes”, Trends in Molecular Medicine, 2010, 16, 584-593, PMCID.
- Cash, KJ, Ricci, F, Plaxco, KW, “A General Electrochemical Method for Label-Free Screening of Protein-Small Molecule Interactions”, Chem. Commun. 2009, 6222-6224, PMCID.
- Cash, KJ, Ricci, F, Plaxco, KW, “An Electrochemical Sensor for the Detection of Protein-Small Molecule Interactions Directly in Serum and Other Complex Matrices”, JACS, 2009, 131, 6955-6957, PMCID.
- Cash, KJ, Heeger, AJ, Plaxco, KW, Xiao, Y, “Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum”, Analytical Chemistry, 2009, 81, 656-661, PMCID.