Associate Professor, Chemical and Biological Engineering
There is a critical need for replacement tissues due to organ failure and tissue loss. The field of tissue engineering seeks to regenerate diseased or damaged tissues by providing the necessary physical, biochemical, and cellular cues that promote tissue regeneration. These approaches typically use biomaterial scaffolds, often with incorporated bioactive factors to help induce the formation of the desired tissue within a defect site. Furthermore, cells can be incorporated into the biomaterial system to help repopulate the defect with the appropriate cell type. In the body, cells are influenced by a large host of factors, including soluble signals such as growth factors, insoluble signals that are components of the extracellular matrix surrounding the cells, and also the interaction of various populations of cells with each other.
Our group is interested in the development of biopolymer systems that will allow the study of cells’ interactions with their microenvironment and that can be used for both tissue regeneration and therapeutics. More specifically, we are investigating the controlled delivery of bioactive factors and therapeutics, the presentation of insoluble signals to cells, the effect of mechanical forces on cell behavior and tissue formation, and the influence that different cell populations have on one another. These advances will lead to improved biomaterial system design criteria. In addition to our tissue engineering research, we are also engineering biopolymer systems for controlled delivery of therapeutic molecules for the treatment of cancer. Ultimately, what we learn in our laboratory will help to improve patient therapies that are available in the clinic.
- BS, MS – University of Rochester
- PhD – Case Western Reserve University
- Post-Doctoral Study – Case Western Reserve University and University of Colorado – Denver
- Fletcher NA, Krebs MD. Sustained Delivery of Anti-VEGF from Injectable Hydrogel Systems Provides Prolonged Decrease of Endothelial Cell Proliferation and Angiogenesis In Vitro. RSC Advances, 2018, 8, 8999.
- Harding J, Osmond M, Krebs MD. Engineering Osteoinductive Biomaterials by Bioinspired Synthesis of Apatite Coatings on Collagen Hydrogels with Varied Pore Microarchitectures. Tissue Engineering Part A, Dec. 1, 2017, 23 (23-24) 1452-65.
- Fletcher NA, Von Nieda EL, Krebs MD. Cell-interactive alginate-chitosan biopolymer systems with tunable mechanics and antibody release rates. Carbohydrate Polymers, Nov. 1, 2017, 175, 765-772.
- Harding J, Krebs MD. Bioinspired Deposition-Conversion Synthesis of Tunable Calcium Phosphate Coatings on Polymeric Hydrogels. ACS Biomaterials Science & Engineering, June 1, 2017, 3(9), 2024-32.
- Osmond M, Bernier SM, Pantcheva MB, Krebs MD. Collagen and Collagen-Chondroitin Sulfate Scaffolds with Uniaxially Aligned Pores for the Biomimetic, Three Dimensional Culture of Trabecular Meshwork Cells. Biotechnology and Bioengineering, 114(4), 915-23, April 11, 2017.
- Riederer MS, Requist BD, Payne KA, Way JD, Krebs MD. Injectable and microporous scaffold of densely-packed, growth factor-encapsulating chitosan microgels. Carbohydrate Polymers, 152, 792-801, 2016.
- Sener G, Krebs MD. Zwitterionic Cryogels for Sustained Release of Proteins. RSC Advances, 6, 29608-11, March 17, 2016.