Melissa Krebs

Associate Professor, Chemical and Biological Engineering

Melissa KrebsThere is a critical need for replacement tissues due to organ failure and tissue loss. The field of tissue engineering seeks to regenerate diseased or damaged tissues by providing the necessary physical, biochemical, and cellular cues that promote tissue regeneration. These approaches typically use biomaterial scaffolds, often with incorporated bioactive factors to help induce the formation of the desired tissue within a defect site. In the body, cells are influenced by a large host of factors, including soluble signals such as growth factors, insoluble signals that are components of the extracellular matrix surrounding the cells, and also the interaction of various populations of cells with each other.

Our group is interested in the development of biopolymer systems that will allow the study of cells’ interactions with their microenvironment and that can be used for tissue regeneration and therapeutics. We are investigating the controlled delivery of bioactive factors and therapeutics, the presentation of insoluble signals to cells, the effect of mechanical forces on cell behavior and tissue formation, and the influence that different cell populations have on one another. These advances will lead to improved biomaterial system design criteria. The applications that we are researching include growth plate cartilage regeneration, trabecular meshwork cell behavior that is important in glaucoma, diabetic wound healing, and bone and dental tissue regeneration. Ultimately, what we learn in our laboratory will help to improve patient therapies that are available in the clinic.

Contact

431 Alderson Hall
1613 Illinois Street
Golden, CO 80401
Office: (303) 273-3983
Fax: (303) 273-3730
mdkrebs@mines.edu

Research Group

  • Bikram Adhikari, University of New Orleans
  • Matthew Osmond, PhD, Colorado School of Mines
  • Michael Stager, University of New Mexico
  • Kathryn Scherrer, Colorado School of Mines
  • Benjamin Stinson, Colorado School of Mines

Krebs Research Group Website

Education

  • BS, MS – University of Rochester
  • PhD – Case Western Reserve University
  • Post-Doctoral Study – Case Western Reserve University and University of Colorado Anschutz Medical Campus

Selected Publications

  • Erickson CB, Newsom JP, Fletcher NA, Feuer ZM, Yu Y, Rodriguez-Fontan F, Hadley-Miller N, Krebs MD, Payne KA. In Vivo Degradation Rate of Alginate-Chitosan Hydrogels Influences Tissue Repair Following Physeal Injury. Journal of Biomedical Materials Research: Part B – Applied Biomaterials, Accepted Jan. 25, 2020.
  • Sener G*, Hilton SA*, Osmond MJ, Zgheib C, Newsom JP, Dewberry L, Singh S, Sakthivel TS, Seal S, Liechty KW*, Krebs MD*. Injectable, Self-Healable Zwitterionic Cryogels with Sustained MicroRNA-Cerium Oxide Nanoparticle Release Promote Accelerated Wound Healing. Acta Biomaterialia, 101, 262-72, January 1, 2020.
  • Osmond MJ, Mizenko RR, Krebs MD. Rapidly Curing Chitosan Calcium Phosphate Composites as Dental Pulp Capping Agents. Regenerative Medicine Frontiers, e190002, May 8, 2019.
  • Newsom JP, Payne KA, Krebs MD. Microgels: Modular, tunable constructs for tissue regeneration. Acta Biomaterialia, 88, 32-41, April 1, 2019.
  • Fletcher NA, Krebs MD. Sustained Delivery of Anti-VEGF from Injectable Hydrogel Systems Provides Prolonged Decrease of Endothelial Cell Proliferation and Angiogenesis In Vitro. RSC Advances, 8, 8999, 2018.
  • Harding J, Krebs MD. Bioinspired Deposition-Conversion Synthesis of Tunable Calcium Phosphate Coatings on Polymeric Hydrogels. ACS Biomaterials Science & Engineering, 3(9), 2024-32, June 1, 2017.
  • Harding J, Osmond M, Krebs MD. Engineering Osteoinductive Biomaterials by Bioinspired Synthesis of Apatite Coatings on Collagen Hydrogels with Varied Pore Microarchitectures. Tissue Engineering Part A, 23 (23-24) 1452-65, Dec. 1, 2017.

Google Scholar Citations Page

 

Honors and Awards